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Synthetic (recombinant) or naturally occuring growth hormone from the human pituitary gland. It is given to children with open epiphyses for the treatment of pituitary dwarfism. Chemical name: Somatotropin (human) (12 Dec 1998)
Somatotropins, recombinant: Somatotropin prepared by recombinant DNA technology. Several different forms have been developed from humans, cows, and pigs. They have been used to help stimulate growth. (12 Dec 1998)
Somatotropin:: <protein> Hormone (191 amino acids) released by anterior pituitary that stimulates release of somatomedin, thereby causing growth. (18 Nov 1997)
Human Growth Hormone is one of the many endocrine hormones, like estrogen, progesterone, testosterone, melatonin, and DHEA, which decline with age (and other factors, such as stress, alcohol, illnesses, etc.) While many of these hormones can be replaced to deter some of the effexcts of aging, hGH reaches far beyond the scope of any one of these hormones to not only prevent biological aging, but to significantly reverse a broad range of the signs and symttoms associated with aging. In effect, hGH therapy has een shown to turn back the biological clock by 20 years or more!
HGH, also known as somatropin, is the most abundant hormone secreted by the pituitary gland. It is produced at a rate that peaks during adolescence when accelerated growth occurs. Daily growth hormone secretion diminishes with age to the extent that a 60 year old may secrete 25% of the hGH secreted by a 20 year old. Growth hormone is primarily released in pulses that take place during the beginning phases of sleep, then it is quickly converted in the liver to its powerful growth promoting metabolite. Insulin-like growth factor type 1 (IGF-1) also known as somatomedin C. IGF-1 promotes glucose transfer through cell membranes as a source of fuel for cells, which is an insulin-l;ike effect. Thus the term IGF-1, or insulin-like growth factor. Most of the beneficial effects of hGH are directly associated with IGF-1.
The decline of growth hormone with age, sometimes referred to as somatopause, is directly associated with many of the symtpoms of aging, including wrinkles, gray hair, decreased energy and sexual function, increased body fat and cardiovascular disease, osteoporosis, and more.
(From "Growth Hormone: Reversing Human Aging Naturally, The Methuselah Factor" by James Jamieson & Dr. I. E. Dorman with Valerie Marriott" Third Edition)