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This is a very significant study by a team of researchers from the University of Hawaii led by Annie Hirazumi. Ms. Hirazumi became interested in the study of the Noni fruit because of earlier experiences with its amazing qualities. Her father helped a good friend with the juice of the Noni, and later, Annie administered the pure Noni juice to a pet dog who was dying. The dog recovered miraculously, and Annie set out to find out more about this incredible fruit. The study by Ms. Hirazumi and her colleagues was conducted on live laboratory mice (specifically C57BL/6 mice) specifically identified as very receptive to injected Lewis Lung Carcinoma cells. The mice were injected with active Lewis Lung Carcinoma cells (LLC). Untreated, the mice died from 9-12 days after injection from the tumor growth. A portion of the injected mice were treated with Noni juice in five separate daily treatments. The Noni juice was shown to significantly increase the life span of the treated mice (from 105% 123%) with 9 of the 22 mice surviving for more than 50 days. The experiment was repeated on a different lot of mice with similar results. The Research Team concluded that the Noni juice: seems to act indirectly by enhancing host immune system involving macrophages and/or lymphocytes.
Induction of Normal Phenotypes in RAS transformed cells by Damnacanthal from Morinda Citrifolia.
T. Hiramatsu, M. Imoto, T Koyano, K. Umezawa Cancer Letters 73 (1993) 161-166
In this study, a team of Japanese researchers studied the effect of over 500 extracts from tropical plants on the K-ras-NRK cell (a pre cursor to certain types of cancer). The compound, damnacanthal, found in the Morinda Citrifolia (Noni), was found to be an inhibitor of Ras function. The research: Ras cells were seeded into 96 plates and incubated at 33 degrees centigrade for 24 hours. The Noni plant extract was added and the cell morphology was examined every day for five days.
The Ras function was inhibited by the injected plant extract. This same compound has been found to inhibit the Epstein-Barr virus early-antigen activation. The extract from the Morinda Citrifolia was found to be most effective in inhibiting Ras function among the 500 tested extracts.
Phytochemicals Reverse Cancer
The power of phytochemicals to promote good health and control cancer is so impressive that the University of Illinois has created a whole new department with 63 scientists and professors to specialize in phytochemical research! Let me share with you some of the scientific findings leading to this major change in research.
Senior Science Advisor to the U.S. Public Health Service, Dr. D.L. Davis states, "Phytochemicals can take tumors and defuse them. They can turn off the proliferative process of cancer." At Ohio State University's Cancer Prevention Laboratory, Dr. Mark Morse and colleagues found that phytochemicals in broccoli known as sulforaphane could reduce esophegeal tumor incidence by as much as 40% and reduce the multiplication of such cancer cells by 90%. Dr. Paul Taladay working at John Hopkins Medical Institute has found that this same phytochemical protected animals from getting cancer even when exposed to cancer causing chemicals. According to Dr. Joseph Hotchkiss of Cornell University, the phytochemicals coumaric acid and chlorogenic acid are able to eliminate many cancer causing substances from the body. An epidemiologist at the University of Minnesota, Dr. John Potter, told Newsweek Magazine, "At almost every step along the pathway to cancer, phytochemicals slow up or reverse the process." Most of these phytochemicals studied so far are found in ordinary vegetables and culinary herbs. The problem is that the amount in these foods is so low that only if you eat a lot of them for a long time will they give you protection. If you already have cancer, what you need is a plant that has these phytochemicals in large enough amounts to go right to work.
Noni Is A Treasure Chest Of Phytochemicals
When plant scientists at the U.S. Department of Agriculture studied the amazing Noni plant they quickly found the secret to its amazing health building power. It is endowed with a greater number and variety of health giving phytochemicals than just about any plant known. Dr. James A. Duke is one of the world's most highly respected scientific authorities on herbs and their phytochemical content. In his authoritative CRC Handbook on Phytochemicals he has listed 23 different phytochemicals found in Noni as well as 5 vitamins and 3 minerals. Research on Noni continues at an ever increasing pace with more of its phytochemicals being uncovered all the time.
IT IS THE INCREDIBLE POWER OF THESE PHYTOCHEMICALS THAT ARE PRODUCING THE WONDERFUL HEALTH BUILDING RESULTS DOCTORS AND PATIENTS ARE NOW SEEING AS A RESULT OF USING THIS AMAZING FRUIT! AS SAFE TO USE AS ANY FRUIT ON THE MARKET.
The U.S. Food and Drug Administration, as well as the Department of Agriculture maintain a list of plants that have no known harmful ingredients and which over the test of time with large numbers of people have proven themselves to be safe for human consumption by the general population. This is known as the GRAS list, and it stands for Generally Recognized As Safe.5 Based on the fact that after careful scientific analysis no harmful ingredients were found, and that the Hawaiian and Polynesian people have been using this health building herb without harm for thousands of years, NONI HAS BEEN OFFICIALLY DESIGNATED AS GENERALLY RECOGNIZED AS SAFE.
Even though Noni is extremely safe, I would always suggest that the introduction of a new herb into the diet be approached with caution by anyone known to have food sensitivities, allergies, or asthma. I would also caution a woman who is pregnant or nursing to consult her physician before using Noni or any other herb.
How Noni Helps The Body Fight Off Cancer!
Researchers at the University of Hawaii School of Medicine introduced cells containing a strain of lung cancer known as Lewis Lung Carcinoma into a group of mice especially bred to be highly susceptible to this type of cancer. Within 9 to 12 days the mice which were given no Noni were all dead as a result of the growth of the tumor. However, another group of these same mice were given an extract of the Noni fruit on five different occasions. At the end of the 12 days when all the untreated mice were dead, those given the Noni were still alive and doing well! At the end of 24 days, the Noni treated mice were all still going strong, this was a 100% extension of life! Actually, 40% which is 9 out of the 22 mice given the Noni, survived for more than 50 days. This is a lifespan more than 4 times greater than the longest living mouse not receiving the Noni. This an incredible achievement! Now remember, these were not just any mice, these mice were specifically bred to succumb to this form of cancer. In this regard, they were "genetically doomed" to be cancer victims. Yet in spite of this, a simple Noni extract gave these mice as much as 4 times the life span of their untreated relatives.
How Noni Did It
I know you are as excited about what you just read as I am, but the best part may be how the Noni made this incredible achievement possible! Most people would just assume something in the Noni had killed the cancer cells. But like all good scientists, the researchers at the University of Hawaii School of Medicine wanted to know exactly how Noni had accomplished its miracle. What they found was quite surprising, and very important. They discovered that there was nothing in their Noni extract that killed the cancer cells. What they discovered was that there was a polysaccharide compound (6-D-glucopyranose pentaacetate) found in the Noni that INCREASED THE ABILITY OF THE IMMUNE SYSTEM TO PRODUCE CHEMICALS THAT ENHANCED THE KILLING POWER OF THE WHITE BLOOD CELLS.
Do you realize the great significance of that discovery? You see white blood cells have to kill many things besides cancer cells. They have to defend us against virus, bacteria, yeast, ameba, parasites and all types of invaders. Since this Noni polysaccharide worked by increasing the overall killing power of the white blood cells, this means it will most likely enhance that same killing power against any invader. It indicates Noni is very likely an overall immune enhancing substance that may provide that little extra which gives you the winning edge when some invading organism attacks your body.
More Cancer Fighting Power Is Found!
Japanese scientists were looking for a substance to fight cancer. They searched through over 500 different extracts from tropical plants looking for something which would inhibit the growth of RAS cancer cells. These are a particular type of fast growing and very malignant cancer cells that are hard to stop. Reporting in the journal Cancer Letters, the scientists stated that the Noni extract was by far the most effective at inhibiting and normalizing RAS transformed cancer cells. RAS is a normal part of the cell structure in every cell. It is a small protein which is part of the RNA of the cell and encodes for the reproduction of the cell. Only when it is activated by a carcinogenic protein within the cell does it trigger the cells to reproduce wildly. If you can turn off this uncontrolled RAS activity, you stop the cancers growth.8, 9. What the Japanese scientists found was that one of the phytochemicals in the Noni extract does exactly that! They found that it was the phytochemical in the Noni extract which goes by the fancy name of Damnacanthal that does this. When they added the Noni extract to RAS activated cancer cells they observed them daily for five days. What they saw was incredible !
They reported that slowly, day by day the cells began to change their morphology (cell structure) back to normal. It is only on the basis of this kind of hard science that doctors can rely upon the ability of a plant extract to produce the return to good health now being seen clinically by people who have been struggling with cancer. No one knows if Noni will produce a return to good health for any specific person, but the research shows there is a scientific basis for believing that it is possible. The above represent only a sample of the research completed on the Morinda Citrifolia plant. The results are conclusive in each case in showing the validity of the traditional use of the Noni.
Analgesic and Behavioral Effects of Morinda Citrifolia
C. Younos, A. Rolland, J. Fleurentin, M. Lanhers, R. Misslin, F. Mortier Planta Medica 56 (1990) 430-434
In this study, the team lead by French scientist Chafique Younos, tested the analgesic and sedative effects of extracts from the Morinda Citrifolia plant. They were aware of the traditional use of the plant as a general analgesic, and set out to determine if those claims were valid. The extract was shown to be non-toxic and did "show a significant, dose-related, central analgesic activity in the treated mice." This study included various experiments on the treated mice to determine the analgesic effect, if any, from the plant extracts of the Morinda Citrifolia (Noni). The conclusion of these researchers was that the extract did in fact demonstrate analgesic effects consistently in each experiment. The conclusion of this study included a simple statement from the authors: "These findings validate the traditional analgesic properties of this plant " The above represent only a sample of the research completed on the Morinda Citrifolia plant. The results are conclusive in each case in showing the validity of the traditional use of the Noni.
References Cited In The Text
1..Limehouse,DVM, John B., Letter publicly circulated, dated February 6, 1997
2..Hall, M.D., Steven M., Statement publicly circulated, dated January 7, 1997
3..Phytochemicals, 1994, Newsweek Magazine, April 25
4..Duke, PhD, James A., Handbook of Phytochemicals, Published by CRC Publishing, Boca Raton, Fl.
6..Hirazumi, A, et al, 1994, Proceedings Western Pharmacology Society, 37: 145-146
7..Hirazumi, A., et al, 1996, Proceedings Western Pharmacology Society, 39: 7 - 9
8..Sylvester, Edward, J., 1986, Target Cancer, Charles Scribner's Sons,N.Y., 9. Fackelman, K., 1997, Science News, 151: 274-275
9..Hiramatsu, M, et al, 1993, Cancer Letters, 73: 161-66
10..Lanettia, 1997, Carbohydrate Antigen 19- 9 Lab Report, SmithKline Beecham Clinical Laboratories
11..Consuela, 1997, Carbohydrate Anitgen 19 9 Lab Results, Private Communication
12..Levland, 0, & Larson, H.O., 1979, Some Chemical Constituants of Morinda Citrifolia (Noni), Planta Medica, 36: 186 -87
13..Koumaglo, K., et al, 1992, Planta Medica, 58: 6
14..Younos, C et al, 1990, Planta Medica, 56: 5
15..Heinicke, Ralph, M., 1985, Bulletin National Tropical Garden, Hawaii
UH Studying Noni Plant On Cancer
Researchers Get $340,000 For Two-Year Study
HONOLULU, 9:00 p.m. HST July 16, 2001 -- The University of Hawaii is about to begin groundbreaking research into a potential treatment for cancer that can be found almost everywhere throughout the Hawaiian Islands.
Researchers want to find out if the extract of the noni plant (pictured, left) has anti-cancer properties. The plant has been used for hundreds of years by Native Hawaiians of medicinal purposes, but it is the first time that its effects will be scientifically studied.
"It's been used a lot as a restorative, as a tonic," Dr. Brian Issell of the UH Cancer Research Center said.
The noni plant is believed to have anti-cancer properties, and can control high blood pressure, diabetes and heart disease.
"Part of the study is to look at what chemicals that are in noni that get into the blood and may be responsible for the anti-cancer activity," Issell said.
Issell and his research team have been awarded $340,000 by the National Institutes of Health to conduct the two-year study on 30 cancer patients who have undergone standard treatments.
Noni research in the laboratory has successfully stopped cancer, according to Issell. Outside of the lab, people normally drink the fermented liquefied extract of the noni plant.